Does Phenylephrine Affect Heart Rate?

What does phenylephrine do to the heart?

Phenylephrine is an α-receptor agonist without β-agonist activity.

Its administration causes vasoconstriction and an increase in arterial blood pressure, and a decrease in heart rate.

Cardiac output may decrease13,27,28 or increase..

What are the side effects of phenylephrine?

Mild upset stomach, trouble sleeping, dizziness, lightheadedness, headache, nervousness, shaking, or fast heartbeat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This product may reduce blood flow to your hands or feet, causing them to feel cold.

What happens when you take too much phenylephrine?

They can help make sure you or your child doesn’t take more than one medication that contains phenylephrine. If you take too much, symptoms of an overdose of Sudafed PE can include: headache. dizziness.

What nasal decongestant is safe with high blood pressure?

For those with high blood pressure, phenylephrine is an alternative to pseudoephedrine. They are in the same drug class known as nasal decongestants, which help relieve sinus congestion and pressure. You can buy products containing phenylephrine right off the shelf at the pharmacy.

Does phenylephrine reduce fever?

Acetaminophen and phenylephrine is a combination medicine used to treat headache, fever, body aches, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Is phenylephrine a stimulant?

Is phenylephrine a stimulant? Phenylephrine does stimulate alpha-adrenergic receptors which may make it responsible for central nervous system stimulant effects such as restlessness, anxiety, and insomnia.

Does phenylephrine raise blood pressure?

Topical nasal decongestants such as Afrin (oxymetazoline), Neo-Synephrine (phenylephrine), Privine (naphazoline), and Vicks VapoRub Inhaler (l-desoxyephedrine/levmetamfetamine) can also cause an increase in blood pressure.

How long does phenylephrine stay in your system?

The elimination half life of phenylephrine is about 2.5 to 3.0 hours.

Is phenylephrine an antihistamine?

What is diphenhydramine and phenylephrine? Diphenhydramine is an antihistamine. Phenylephrine is a decongestant. Diphenhydramine and phenylephrine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Is phenylephrine a beta blocker?

Phenylephrine is an alpha1 agonist with very little beta effect. Its major action is systemic and pulmonary arterial vasoconstriction, increasing SVR and systemic arterial pressure (systolic, diastolic, and mean).

Can phenylephrine cause bradycardia?

Learning Objectives: Phenylephrine is a synthetic catecholamine that increases systemic vascular resistance via activation of alpha receptors. A known side effect of phenylephrine is reflex bradycardia due to activation of the baroreceptor. However, the duration of this effect is not well described.

When should phenylephrine be avoided?

overactive thyroid gland. acidosis, a high level of acid in the blood. high blood pressure. significant uncontrolled high blood pressure.

Which one is better phenylephrine or pseudoephedrine?

Effectiveness. Studies in 2006 and 2009 found pseudoephedrine to be more effective than phenylephrine in the treatment of nasal congestion.

Will phenylephrine make me sleepy?

Decongestants. Since the main symptom of a cold is congestion in your nose and/or chest, cold medicines usually contain a decongestant ingredient. Examples include phenylephrine and pseudoephedrine. These typically do not cause drowsiness and can make some people feel hyper or more alert.

What is the most effective sinus decongestant?

Best Overall: GoodSense Nasal Decongestant. … Best Natural: Vicks Cool Mist Humidifier. … Best Spray: Flonase Allergy Relief Nasal Spray. … Best for Colds: Mucinex Sinus-Max Liquid. … Best for Sinus Infections: Sudafed PE Pressure + Pain + Relief. … Best Neti Pot: ComfyPot Ergonomic Ceramic Neti Pot.More items…

What drugs interact with phenylephrine?

Severe Interactions of phenylephrine include:iobenguane I 123.isocarboxazid.linezolid.phenelzine.procarbazine.selegiline transdermal.tranylcypromine.

What is the difference between norepinephrine and phenylephrine?

There are no differences between norepinephrine and phenylephrine in terms of systemic hemodynamics when they are administered as a first-line vasopressor agent in septic shock. Phenylephrine is less effective than norepinephrine to counteract sepsis-related arterial hypotension.

Can Levophed cause bradycardia?

Overdosage with LEVOPHED may result in headache, severe hypertension, reflex bradycardia, marked increase in peripheral resistance, and decreased cardiac output.

Why does phenylephrine decrease heart rate?

Most textbooks and review articles contain a table showing a reduction in cardiac output from phenylephrine (example above). The usual explanation is that phenylephrine increases systemic vascular resistance (afterload), which makes it harder for the heart to pump blood forward.

Who should not take phenylephrine?

do not take phenylephrine if you are taking a monoamine oxidase (MAO) inhibitor, such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 2 weeks.

How long does it take phenylephrine to work?

The decongestant effect of phenylephrine in cold or flu remedies should be noticeable within approximately 30 minutes. A rapid increase in blood pressure is usually seen following an intravenous dose that persists for up to 20 minutes.